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Biology & Biological Sciences

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What is Biology & Biological Sciences?

Biology is the fascinating and ever-expanding field dedicated to studying life on Earth. It encompasses all living organisms, from the microscopic world of bacteria to the towering giants of the redwood forest. Biologists delve into the structure, function, growth, origin, evolution, and distribution of life across the planet.

What are the main topics involved with Biology & Biological Sciences?

  • Biochemistry: Focuses on the chemistry of life, exploring the structure, function, and interactions of molecules essential for biological processes.
  • Cell Biology: Examines the fundamental unit of life, the cell, its structure, function, and how different cell types work together in an organism.
  • Genetics: Investigates genes, heredity, and how traits are passed down from generation to generation.
  • Microbiology: Studies microscopic organisms like bacteria, archaea, viruses, and fungi, and their impact on health and the environment.
  • Molecular Biology: Zooms in on the role of molecules like DNA and RNA in cellular processes and heredity.
  • Zoology: Delves into the animal kingdom, its diversity, behavior, evolution, and conservation.
  • Botany: Focuses on plants, their structure, physiology, ecology, and evolution.
  • Ecology: Examines the interactions between living organisms and their environment, including how populations, communities, and ecosystems function.
  • Evolutionary Biology: Studies how living things change over time and the mechanisms that drive this change, such as natural selection.

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What is biology?

What is biology?

Biology is the fascinating and ever-expanding field dedicated to studying life on Earth. It encompasses all living organisms, from the microscopic world of bacteria to the towering giants of the redwood forest. Biologists delve into the structure, function, growth, origin, evolution, and distribution of life across the planet.

What are the main features of biology?

  • Diversity of Life: Biology celebrates the incredible variety of life forms, from single-celled organisms to complex ecosystems teeming with interacting species.
  • Unity in Diversity: Despite this vast diversity, there are unifying principles that tie all living things together. These include the use of DNA as genetic material and the processes of cellular respiration and photosynthesis, which power life.
  • Scientific Approach: Biologists rely on the scientific method to ask questions about living things. They gather evidence through observation and experimentation, and form testable hypotheses to understand the natural world.

What are important sub-areas in biology?

Due to the immense breadth of biology, specialization is essential. Here are some of the most prominent sub-areas:

  • Biochemistry: Focuses on the chemistry of life, exploring the structure, function, and interactions of molecules essential for biological processes.
  • Cell Biology: Explores the fundamental unit of life, the cell. It examines cell structure, function, and how different cell types work together in an organism.
  • Genetics: Investigates genes, heredity, and how traits are passed down from generation to generation.
  • Microbiology: Studies microscopic organisms like bacteria, archaea, viruses, and fungi, and their impact on health and the environment.
  • Molecular Biology: Zooms in on the role of molecules like DNA and RNA in cellular processes and heredity.
  • Zoology: Delves into the animal kingdom, its diversity, behavior, evolution, and conservation.
  • Botany: Focuses on plants, their structure, physiology, ecology, and evolution.
  • Ecology: Examines the interactions between living organisms and their environment, including how populations, communities, and ecosystems function.
  • Evolutionary Biology: Studies how living things change over time and the mechanisms that drive this change, such as natural selection.

What are key concepts in biology?

  • Cell Theory: The cornerstone of biology, stating that all living things are composed of cells, the basic units of life.
  • DNA: Deoxyribonucleic acid, the molecule that carries genetic information and is responsible for heredity.
  • Evolution by Natural Selection: The theory proposed by Charles Darwin, explaining how organisms with favorable traits are more likely to survive and reproduce, leading to evolution of populations over time.
  • Homeostasis: The ability of an organism or a biological system to maintain a stable internal environment despite external changes.
  • Metabolism: The sum of all chemical reactions that occur in living organisms, allowing them to grow, reproduce, maintain their structure, and respond to their environment.

Who are influential figures in biology?

  • Louis Pasteur: A French microbiologist whose discoveries on vaccines and fermentation had a profound impact on public health.
  • Charles Darwin: A British naturalist who revolutionized our understanding of life with his theory of evolution by natural selection.
  • Gregor Mendel: An Austrian monk considered the father of genetics for his pioneering work on inheritance
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Developmental Biology: The best concepts summarized

Developmental Biology: The best concepts summarized

Developmental Biology: The best concepts summarized

A short introduction to the best concepts of developmental biology: From a zygote to a vertebrate.

What is developmental biology?

What is developmental biology?

Developmental biology is the scientific study of how organisms grow and develop from a single cell (zygote) to their final form. It explores the underlying genetic and environmental factors that shape the development of various tissues, organs, and body structures.

What are the main features of developmental biology?

  • Interdisciplinary field: It draws on insights from genetics, molecular biology, cell biology, embryology, and evolutionary biology.
  • Focus on pattern formation: It investigates how cells organize themselves into specific patterns and structures during development.
  • Key stages of development: Developmental biologists study key stages of development, including fertilization, cleavage, gastrulation, organogenesis, and metamorphosis.

Why is developmental biology important?

  • Understanding life processes: It provides fundamental insights into the mechanisms that govern the growth and development of all living organisms.
  • Medical applications: Developmental biology has significant implications for medical research, including the study of birth defects, regenerative medicine, and cancer biology.
  • Evolutionary biology: It helps us understand the evolutionary origins of different body plans and the genetic changes that underlie them.

What are applications of developmental biology?

  • Stem cell research: Understanding developmental processes can help us harness the potential of stem cells for regenerative medicine.
  • Cancer research: Studying developmental pathways can shed light on the mechanisms that drive cancer development and progression.
  • Drug discovery: Developmental biology can be used to identify new drug targets for treating diseases related to developmental defects.
  • Agricultural biotechnology: Understanding plant development can help improve crop yields and resistance to pests and diseases.

Example

One classic example of developmental biology research is the study of Drosophila melanogaster (fruit flies). Fruit flies have been used extensively as a model organism to investigate the genetic basis of development, providing valuable insights into fundamental developmental processes.

Critical comments

  • Complexity: Developmental processes are highly complex and involve a multitude of interacting factors.
  • Ethical considerations: Research on embryonic development raises ethical concerns, particularly when involving human embryos or stem cells.
  • Species-specific differences: While many developmental principles are conserved across species, there can be significant differences in the details of development.
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What is biological ethics?

What is biological ethics?

Biological ethics is a branch of applied ethics that deals with moral issues arising from the study and application of biology. It encompasses a wide range of topics, including:

  • Genetics: Issues related to genetic testing, genetic engineering, and gene therapy
  • Medicine: Ethical considerations in medical research, patient autonomy, and end-of-life care
  • Animal welfare: Ethical treatment of animals in research, agriculture, and entertainment
  • Environmental ethics: Issues related to biodiversity conservation, climate change, and sustainable resource use

What are the main features of biological ethics?

  • Interdisciplinary nature: It draws on insights from philosophy, sociology, law, and other disciplines.
  • Complex issues: Biological ethics often involves complex moral dilemmas with no easy solutions.
  • Balancing competing interests: Biological ethics seeks to balance the interests of individuals, animals, and society as a whole.

Why is biological ethics important?

  • Guiding research and practice: Biological ethics provides a framework for making morally sound decisions in scientific research and medical practice.
  • Protecting human rights: It helps to protect the rights of individuals, such as the right to privacy and informed consent.
  • Promoting animal welfare: It ensures that animals are treated ethically in research, agriculture, and other contexts.
  • Addressing environmental concerns: It helps to address pressing environmental issues, such as climate change and biodiversity loss.

What are applications of biological ethics?

  • Informed consent: Ensuring that individuals provide informed consent for medical procedures and research participation.
  • Animal welfare guidelines: Developing and enforcing guidelines for the ethical treatment of animals in research and other settings.
  • Genetic counseling: Providing guidance to individuals and families facing genetic health issues.
  • Policy development: Developing policies related to issues such as stem cell research, gene editing, and environmental conservation.

Example

A classic example of a biological ethics dilemma is the debate over stem cell research. While embryonic stem cells offer great potential for medical advancements, their use raises ethical concerns about the destruction of human embryos. Biological ethics can help to navigate this complex issue by considering the potential benefits and harms of different approaches.

Critical comments

  • Cultural and religious differences: Biological ethics can be influenced by cultural and religious beliefs, which can make it challenging to reach universal consensus.
  • Rapid technological advancements: The rapid pace of technological advancements in biology can outpace the development of ethical guidelines, creating a need for ongoing reflection and adaptation.
  • Subjectivity: Some aspects of biological ethics involve subjective judgments about values and priorities, which can make it difficult to reach definitive conclusions.
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What is a zygote?

What is a zygote?

A zygote is the single-celled organism that forms when a sperm cell fertilizes an egg cell. It represents the initial stage of life for a new individual.  

What are the main features of a zygote?

  • Diploid: Contains a complete set of chromosomes, half from each parent.  
  • Totipotent: Has the potential to develop into any type of cell in the body.
  • Undergoes rapid division: The zygote undergoes a process called cleavage, where it rapidly divides into multiple cells.  

Why is the zygote important?

  • Genetic blueprint: It carries the genetic information that will determine the traits of the developing organism.  
  • Foundation of development: The zygote is the starting point for the entire process of embryonic development.  
  • Basis of reproduction: The formation of a zygote is essential for sexual reproduction.

What are the applications of zygote research?

  • In vitro fertilization (IVF): Zygotes are created in a laboratory setting to assist in fertility treatments.
  • Stem cell research: Zygotes can be used to derive embryonic stem cells, which have the potential to differentiate into various cell types.
  • Genetic testing: Zygotes can be tested for genetic disorders before implantation, a process known as preimplantation genetic diagnosis (PGD).  

Example

A fertilized human egg cell is a zygote. It begins its journey through the fallopian tube, eventually implanting in the uterine wall and developing into an embryo.  

Critical comments

  • Ethical concerns: The use of zygotes in research, particularly embryonic stem cell research, raises ethical questions about the beginning of life and the destruction of potential human beings.
  • Limitations: While zygotes have immense potential, their development is influenced by a complex interplay of genetic and environmental factors, making it difficult to fully understand and control.
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What is Sonic hedgehog?

What is Sonic hedgehog?

Sonic hedgehog (Shh) is a secreted signaling protein that plays a crucial role in embryonic development and tissue patterning in various organisms. It is a member of the Hedgehog family of proteins, which are highly conserved across different species.

What are the main features of Sonic hedgehog?

  • Morphogen: Shh acts as a morphogen, meaning it can influence the development of different cell types and tissues based on its concentration gradient.
  • Patterning: Shh is involved in the patterning of various structures, including the nervous system, limbs, and facial features.
  • Regulation: The activity of Shh is tightly regulated by a complex network of signaling pathways and feedback mechanisms.

What is the importance of Sonic hedgehog?

Shh is essential for proper embryonic development and the formation of various organs and tissues. Dysregulation of Shh signaling can lead to birth defects and developmental disorders.

What are the applications of Sonic hedgehog in practice?

Understanding Shh signaling has significant implications for medicine and research. Some applications include:

  • Stem cell research: Shh can be used to induce the differentiation of stem cells into various cell types, such as neurons and muscle cells.
  • Cancer research: Shh signaling is implicated in the development and progression of certain types of cancer, and targeting Shh pathways may be a potential therapeutic strategy.
  • Developmental biology: Studying Shh signaling can help researchers understand the mechanisms that underlie the formation of complex structures and patterns during embryonic development.

Example

A well-known example of Shh signaling is its role in limb development. Shh is produced in the zone of polarizing activity (ZPA) at the posterior end of the limb bud. The concentration gradient of Shh across the limb bud helps to determine the patterning of digits, with the thumb being formed by cells exposed to the highest concentration of Shh and the pinky finger being formed by cells exposed to the lowest concentration.

Critical comments

While Shh is a well-studied signaling molecule, there are still many unanswered questions about its precise mechanisms of action and regulation. Further research is needed to fully understand the complex interactions between Shh and other signaling pathways that contribute to embryonic development and tissue patterning.

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What is sexual reproduction?

Sexual reproduction is a mode of reproduction that involves the fusion of genetic material from two different parents to create offspring. This process results in offspring with a unique combination of genes, leading to genetic variation within a population.

What are the key features of sexual reproduction?

  • Two Parents: Sexual reproduction requires two individuals, typically of the same species but with different genetic makeup, to contribute gametes (sex cells) for fertilization.
  • Gamete Formation: Meiosis, a specialized cell division process, produces haploid gametes (eggs and sperm) containing half the number of chromosomes compared to the parent.
  • Fertilization: Fusion of a sperm and an egg (gametes) during fertilization creates a diploid zygote, the fertilized egg that initiates the development of a new individual.

What is the importance of sexual reproduction?

Sexual reproduction offers several advantages over asexual reproduction:

  • Genetic Variation: By shuffling genes from two parents, sexual reproduction creates offspring with unique genetic
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What is asexual reproduction?

Asexual reproduction is a mode of reproduction where a single parent organism gives rise to genetically identical offspring. This process is often faster and less resource-intensive than sexual reproduction.

What are the key features of asexual reproduction?

  • Single Parent: Unlike sexual reproduction, asexual reproduction only requires one parent. This parent can reproduce independently, without the need to find a mate.
  • Offspring Similarity: Offspring produced through asexual reproduction are genetically identical to the parent organism. They inherit the exact same DNA copy.
  • Variety of Mechanisms: Asexual reproduction can occur through various mechanisms, including mitosis (cell division), budding, fragmentation, and parthenogenesis (development of an egg without fertilization).

What is the importance of asexual reproduction?

Asexual reproduction offers several advantages for organisms:

  • Rapid Population Growth: A single parent can produce a large number of offspring quickly, allowing populations to grow rapidly and exploit favorable environments.
  • Simple and Efficient: Asexual reproduction doesn't require the complexity of
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What are chromosomes?

Chromosomes are the tightly packaged structures within a cell's nucleus that carry an organism's genetic information. They are made up of DNA (deoxyribonucleic acid) and proteins, and act like an instruction manual containing the blueprints for building and maintaining an organism.

What are the key features of chromosomes?

  • DNA Carriers: Chromosomes are composed primarily of DNA, the molecule that encodes the instructions for building and regulating an organism. Each chromosome carries a specific set of genes.
  • Linear Structure: DNA within a chromosome is not randomly packed but rather organized in a linear fashion. This linear arrangement determines gene order and plays a role in gene expression.
  • Number Variation: The number of chromosomes varies between species. Humans have 46 chromosomes (23 pairs), while fruit flies have only 8 and some fern species have hundreds.
  • Duplication and Segregation: Before cell division, chromosomes replicate themselves to ensure each daughter cell receives a complete set of genetic
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What are sex chromosomes?

Sex chromosomes are a special pair of chromosomes in some organisms that determine the biological sex (male or female) of an individual. They differ from the other chromosomes, called autosomes, in both their structure and function.

What are the key features of sex chromosomes?

  • Differing Pair: Unlike autosomes (which come in homologous pairs), sex chromosomes can be a homologous pair (XX) in females or a heterologous pair (XY) in males.
  • Sex-Determining Genes: The Y chromosome carries the sex-determining region (SRY) gene, which triggers the development of male sex organs during embryonic development. The X chromosome lacks this gene and has a different set of genes important for various functions.
  • Varying Sizes: In many species, the X chromosome is larger than the Y chromosome. The Y chromosome often contains fewer genes and may be prone to rearrangements.

What is the importance of sex chromosomes?

Sex chromosomes play a crucial role in:

  • Sex Determination: The presence or absence of
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What are chromatides?

Chromatides are the two identical copies of a chromosome that are joined together at a specific region called the centromere after DNA replication during cell division (mitosis or meiosis). They represent the sister copies of the genetic information contained within a single chromosome.

What are the key features of chromatides?

  • Sister Chromosomes: Each chromatid is a complete copy of the original chromosome, containing the same linear arrangement of genes.
  • Duplication Process: Chromatides form through DNA replication before cell division. The DNA double helix unwinds and each strand serves as a template for synthesizing a new complementary strand, resulting in two identical copies.
  • Centromere Connection: The centromere is a specialized region that holds the two sister chromatids together until they separate during cell division. It also serves as an attachment point for spindle fibers that orchestrate chromosome movement during cell division.
  • Separation During Division: During cell division, the centromere weakens, allowing the sister chromatids
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What is a centromere?

The centromere is a specialized constricted region on a chromosome that plays a critical role in cell division (mitosis and meiosis). It acts like a control center, coordinating the movement and separation of sister chromatids during cell division.

What are the key features of a centromere?

  • Sister Chromatid Connection: The centromere holds the two sister chromatids (replicated copies of a chromosome) together after DNA replication. It ensures they function as a single unit until separation during cell division.
  • Kinetochore Assembly Site: The centromere serves as the attachment point for kinetochores, protein complexes that interact with spindle fibers. These fibers are the cellular "tracks" along which chromosomes move during cell division.
  • Checkpoint Control: The centromere plays a role in cell cycle checkpoints, ensuring proper attachment of all chromosomes to spindle fibers before cell division proceeds. This helps prevent errors in chromosome number in daughter cells.

What is the importance of the

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What is competitive exclusion?

Competitive exclusion, also known as Gause's principle, is an ecological principle stating that two competing species cannot coexist indefinitely in the same environment if they rely on the same limited resources. This principle implies that one species will eventually outcompete the other and drive it to extinction or emigration from that particular niche.

What are key features of competitive exclusion?

  • Resource Overlap: Competitive exclusion applies when two species share the same ecological niche, meaning they require the same essential resources like food, water, or space to survive and reproduce.
  • Limited Resources: The resources needed by both species are limited in quantity, leading to competition for their acquisition.
  • Unequal Competitors: One species will inevitably be more efficient at utilizing the shared resources or better at tolerating competition. This less competitive species will be at a disadvantage.

What is the importance of competitive exclusion?

  • Understanding Community Structure: Competitive exclusion helps explain how communities
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Belangrijke bacteriësoorten die infecties veroorzaken: Bacteriologie en Pathogenese

Stafylococcen

Stafylococcen zijn Grampositieve coccen die in groepen of trossen bijeen gelegen zijn. Ze bezitten geen flagellae, zijn dus niet beweeglijk en kunnen geen sporen vormen. Ze groeien het best onder aerobe omstandigheden, maar groeien soms ook anaeroob. . In tegenstelling tot streptococcen produceren stafylococcen katalase. Meer dan een dozijn soorten stafylococcen koloniseren ons lichaam. De drie bekendste soorten zijn echter de S. aureus, de S. epidermidis en de S. saprophyticus. Wereldwijd is Staphylococcus aureus een van de meest voorkomende oorzaken van acute purulente infecties en onderscheidt het zich van de rest

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What is density dependent birth rate?

Density-dependent birth rate is a phenomenon in population ecology where the birth rate of a population decreases as the population density increases. This occurs because as the population density increases, there are fewer resources available for each individual, such as food, water, and space. This leads to a decrease in the overall health and fitness of the population, which in turn leads to a decrease in the birth rate.

What are key characteristics of density dependent birth rate?

  • Negative relationship: The birth rate is negatively correlated with the population density.
  • Limited resources: The decrease in birth rate is caused by the limited resources available to the population.
  • Various factors: The resources that can be limited include food, water, space, nesting sites, mates, and other factors that are essential for reproduction.

What is the importance of density dependent birth rate?

  • Density-dependent birth rate is an important concept in population ecology because
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What is density dependent death rate?

Density-dependent death rate is a phenomenon in population ecology where the death rate of a population increases as the population density increases. This occurs because as the population density increases, there is an increase in competition for resources such as food, water, and space. This leads to a decrease in the overall health and fitness of the population, which in turn leads to an increase in the death rate.

Key characteristics of density dependent death rate?

  • Positive relationship: The death rate is positively correlated with the population density.
  • Limited resources: The increase in death rate is caused by the limited resources available to the population.
  • Various factors: The limited resources can include food, water, space, nesting sites, mates, and other factors that are essential for survival.

What is the importance of density dependent death rate?

  • Density-dependent death rate is an important concept in population ecology because it helps to explain
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What is epiboly?

Epiboly is a process in embryonic development where a sheet of cells spreads over the surface of another cell mass. It is a fundamental mechanism that contributes to the formation of various structures in the embryo. What are the main features of epiboly?

  • Cell spreading: Cells migrate outwa...

What is the Spemann organizer?

The Spemann organizer, also known as the dorsal blastopore lip, is a small region of tissue in the amphibian embryo that plays a crucial role in determining the body plan. It is named after Hans Spemann, a German embryologist who discovered its importance in the early 20th century. What are the main...

What is developmental biology?

Developmental biology is the scientific study of how organisms grow and develop from a single cell (zygote) to their final form. It explores the underlying genetic and environmental factors that shape the development of various tissues, organs, and body structures. What are the main features of deve...

What is biological ethics?

Biological ethics is a branch of applied ethics that deals with moral issues arising from the study and application of biology. It encompasses a wide range of topics, including:

  • Genetics: Issues related to genetic testing, genetic engineering, and gene therapy
  • Medicine: Ethical con...

What are somites?

Somites are blocks of mesoderm that form on either side of the notochord during embryonic development in vertebrates. They play a crucial role in the formation of various tissues and organs throughout the body. What are the main features of somites?

  • Mesodermal origin: They are derived from ...

What is gastrulation?

Gastrulation is a crucial stage in embryonic development during which the blastula (a hollow ball of cells) reorganizes to form the three primary germ layers: the ectoderm, mesoderm, and endoderm. These germ layers will ultimately differentiate into all the tissues and organs of the developing embry...

What is the notochord?

The notochord is a rod-shaped structure that forms along the dorsal side of the embryo in chordate animals, including vertebrates. It is present during embryonic development and plays a crucial role in the formation of the vertebral column. What are the main features of the notochord?

  • Tempo...

What is the mesoderm?

The mesoderm is one of the three primary germ layers formed during embryonic development. It is the middle layer, located between the ectoderm (outer layer) and the endoderm (inner layer). What are the main features of the mesoderm?

  • Middle layer: It is positioned between the ectoderm a...

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What is a polyphyletic group?

A polyphyletic group is a group of organisms that does not include a common ancestor and all of its descendants. In other words, it's a grouping that is not based on shared evolutionary history. What are the main features of a polyphyletic group?

  • Lack of Common Ancestor: Members of a p...

What is ontogeny?

Ontogeny is the study of the development of an organism from its conception to its death. It encompasses the entire life cycle, including growth, maturation, and aging. What are the main features of ontogeny?

  • Growth: The increase in size and mass of an organism.
  • Development: The pr...

What is a monophyletic group?

A monophyletic group, also known as a clade, is a group of organisms that includes a common ancestor and all of its descendants. In essence, it's a natural grouping that reflects evolutionary relationships.   What are the main features of a monophyletic group?

  • Common Ancestor: All...

What is an exaptation?

An exaptation is a trait that evolved for one purpose but was later co-opted for a different function. In essence, it's a repurposing of an existing feature for a new use. What are the main features of an exaptation?

  • Evolutionary Re-purposing: A trait originally evolved for one function is ...

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What is biological sciences?

Biological sciences, also commonly referred to as biology, is the overarching field dedicated to studying life on Earth in all its forms. It encompasses a vast array of disciplines, each focusing on different aspects of living organisms. What are the main features of biological sciences?

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Summary: Essential Cell Biology (Alberts et al) - Second part

This summary is based on the 3rd edition of Essential Cell Biology from Alberts et al. The first 10 chapters are open access and can be found here: First part of the summary

  • 11. Membrane structure
  • 12. Membrane transport
  • 13. How cells obtain energy from food
  • 14. E...

Summary: Essential Cell Biology (Alberts et al) - First part

This summary is based on the 3rd edition of Essential Cell Biology from Alberts et al. The remaining chapters can be accessed when logged in and can be found here: Second part of the summary

  • 1. Introduction to cells
  • 2. Chemical components of cells
  • 3. Energy, cat...

What is biological sciences?

Biological sciences, also commonly referred to as biology, is the overarching field dedicated to studying life on Earth in all its forms. It encompasses a vast array of disciplines, each focusing on different aspects of living organisms. What are the main features of biological sciences?

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