The JoHo Insurances Foundation is specialized in insurances for travel, work, study, volunteer, internships an long stay abroad
Check the options on joho.org (international insurances) or go direct to JoHo's https://www.expatinsurances.org
What is insertion?
An insertion in DNA duplication refers to a mutation that occurs during the process of copying DNA. It involves the insertion of one or more additional nucleotides (the building blocks of DNA) into a newly synthesized DNA strand.
What are the main features of insertion?
- Mechanism: Insertions can arise due to various mechanisms, including errors by DNA polymerase during replication, the activity of transposable elements (jumping genes), or errors in DNA repair processes.
- Size: Insertions can range from a single nucleotide to larger segments of DNA, depending on the event causing the insertion.
- Consequences: The impact of insertions depends on their location and size. Small insertions might have minimal effects, while larger insertions can disrupt genes, alter protein function, and potentially lead to genetic diseases.
Why is insertion important?
- Understanding insertions is crucial for studying how mutations arise and contribute to genetic variation.
- Some insertions can be beneficial, creating new genetic diversity or introducing regulatory elements that influence gene expression.
- However, insertions can also be detrimental, causing various genetic disorders by disrupting gene function.
How is insertion applied in practice?
- Genetic Testing: Analyzing DNA sequences for insertions helps diagnose genetic diseases caused by such mutations.
- Cancer Research: Studying insertions in cancer genomes can reveal potential drivers of tumor development and identify novel therapeutic targets.
- Genetic Engineering: Scientists can use techniques to deliberately insert specific DNA sequences into an organism's genome for research or biotechnology applications (although this is a tightly controlled area).
Practical example
- Cystic fibrosis (CF) is a genetic disease caused by various mutations in the CFTR gene. Some mutations involve insertions of a few nucleotides, leading to a frameshift mutation. This disrupts the reading frame of the gene, resulting in the production of a nonfunctional protein and the characteristic symptoms of CF.
Critical comments
- Detecting insertions in DNA sequences can be challenging, especially for small insertions.
- The long-term effects of insertions, particularly larger ones, are not always fully understood.
- Ethical concerns exist regarding the deliberate use of insertion techniques in genetic engineering, especially for human germline modification (altering genes in sperm or egg cells).
Access:
Public
Click & Go to more related summaries or chapters:
Study guide with flashcards and definitions with Genomics at Utrecht University
Flashcards and definitions with Genomics
Online flashcards with Genomics
- Centromere
- Chromatides
- Chromosomes
- Sex chromosomes
- Asexual reproduction
- Sexual reproduction
- Mitosis
- Meiosis
- Genomics
- Transcriptomics
- Proteomics
- Metabolomics
- Plasmid
- Polymerase Chain Reaction
- Next Generation Sequencing
- Sanger sequencing
- RNA-sequencing
- CRISPR-Cas9
- Forward genetic screens
- Reverse genetic screens
- RNA interference
- Bioinformatics
- DNA replication
- DNA mutation
- Evolution
- Horizontal gene transfer (HGT)
- Virus
- Microsatellites
- Basic Local Alignment Search Tool (BLAST)
- Findable, Accessible, Interoperable, and Reusable data (FAIR data)
- Phylogenetic tree
- Insertion
- Deletion
- For flashcards and definitions, see the supporting content of this study guide
Summaries and supporting content:
Access:
Public
Genomics: The best concepts summarized
Genomics: The best concepts summarized
Table of contents
- Centromere
- Chromatides
- Chromosomes
- Sex chromosomes
- Asexual reproduction
- Sexual reproduction
- Mitosis
- Meiosis
- Genomics
- Transcriptomics
- Proteomics
- Metabolomics
- Plasmid
- Polymerase Chain Reaction
- Next Generation Sequencing
- Sanger sequencing
- RNA-sequencing
- CRISPR-Cas9
- Forward genetic screens
- Reverse genetic screens
- RNA interference
- Bioinformatics
- DNA replication
- DNA mutation
- Evolution
- Horizontal gene transfer (HGT)
- Virus
- Microsatellites
- Basic Local Alignment Search Tool (BLAST)
- Findable, Accessible, Interoperable, and Reusable data (FAIR data)
- Phylogenetic tree
- Insertion
- Deletion
Summaries and supporting content:
Access:
Public
This content refers to .....
Summaries and Study Assistance - Start
Summaries and Study Assistance - Start
Summaries, study notes, tips and tools for study and know how
For optimal and free use of summaries, study help, exam tickets, practice exams, bullet points notes
- join JoHo WorldSupporter
- then check the study and exam tips;
- study the material through the summaries;
- repeat the material through the bullets or notes
- master the material through the practice exams.
Work for WorldSupporter
JoHo can really use your help! Check out the various student jobs here that match your studies, improve your competencies, strengthen your CV and contribute to a more tolerant world
Check how to use summaries on WorldSupporter.org
Online access to all summaries, study notes en practice exams
- Check out: Register with JoHo WorldSupporter: starting page (EN)
- Check out: Aanmelden bij JoHo WorldSupporter - startpagina (NL)
How and why would you use WorldSupporter.org for your summaries and study assistance?
- For free use of many of the summaries and study aids provided or collected by your fellow students.
- For free use of many of the lecture and study group notes, exam questions and practice questions.
- For use of all exclusive summaries and study assistance for those who are member with JoHo WorldSupporter with online access
- For compiling your own materials and contributions with relevant study help
- For sharing and finding relevant and interesting summaries, documents, notes, blogs, tips, videos, discussions, activities, recipes, side jobs and more.
Using and finding summaries, study notes en practice exams on JoHo WorldSupporter
There are several ways to navigate the large amount of summaries, study notes en practice exams on JoHo WorldSupporter.
- Use the menu above every page to go to one of the main starting pages
- Starting pages: for some fields of study and some university curricula editors have created (start) magazines where customised selections of summaries are put together to smoothen navigation. When you have found a magazine of your likings, add that page to your favorites so you can easily go to that starting point directly from your profile during future visits. Below you will find some start magazines per field of study
- Use the topics and taxonomy terms
- The topics and taxonomy of the study and working fields gives you insight in the amount of summaries that are tagged by authors on specific subjects. This type of navigation can help find summaries that you could have missed when just using the search tools. Tags are organised per field of study and per study institution. Note: not all content is tagged thoroughly, so when this approach doesn't give the results you were looking for, please check the search tool as back up
- Check or follow your (study) organizations:
- by checking or using your study organizations you are likely to discover all relevant study materials.
- this option is only available trough partner organizations
- Check or follow authors or other WorldSupporters
- by following individual users, authors you are likely to discover more relevant study materials.
- Use the Search tools
- 'Quick & Easy'- not very elegant but the fastest way to find a specific summary of a book or study assistance with a specific course or subject.
- The search tool is also available at the bottom of most pages
Do you want to share your summaries with JoHo WorldSupporter and its visitors?
- Check out: Why and how to add a WorldSupporter contributions
- JoHo members: JoHo WorldSupporter members can share content directly and have access to all content: Join JoHo and become a JoHo member
- Non-members: When you are not a member you do not have full access, but if you want to share your own content with others you can fill out the contact form
Quicklinks to fields of study for summaries and study assistance
Field of study
- All studies for summaries, study assistance and working fields
- Communication & Media sciences
- Corporate & Organizational Sciences
- Cultural Studies & Humanities
- Economy & Economical sciences
- Education & Pedagogic Sciences
- Health & Medical Sciences
- IT & Exact sciences
- Law & Justice
- Nature & Environmental Sciences
- Psychology & Behavioral Sciences
- Public Administration & Social Sciences
- Science & Research
- Technical Sciences
Check the related and most recent topics and summaries:
Activity abroad, study field of working area:
Add new contribution