Major issues in integrating research in day-to-day practice include:

• The relative weight to place on different research methods
• The representativeness of research samples
• Whether research results should guide practice at the level of principles of change, intervention strategies, or specific protocols
• The generalizability and transportability of treatments supported in controlled research to clinical practice settings
• The extent to which judgments can be made about treatments of choice when the number and duration of treatments tested has been limited
• The degree to which the results of efficacy and effectiveness research can be generalized from primarily white samples to minority and marginalized populations