1. What do we know about comorbidity between major depressive order and physical diseases?

Why is comorbidity between major depressive disorder and physical diseases a problem?

People with major depressive disorder (MDD) have a greater risk for many physical diseases, and at the same time, populations with physical diseases experience much higher rates of MDD. This comorbidity causes negative outcomes, such as reduced adherence to treatment, greater health care costs, and increased mortality. It also causes clinical difficulties, such as difficulties pertaining adaptive health behaviors, drug interactions, and more complicated therapeutic treatments.

Which diseases appear to be comorbid to MDD?

Major depressive disorder is a risk factor for a range of physical diseases and there is a bidirectional relationship. Identified comorbid diseases are cardiovascular disease, diabetes, metabolic syndrome, cancer, neurological diseases, and osteoporosis. Both MDD and these physical diseases are associated with increases in mortality, and their